PlGF-3

• Description :

  PlGF-3 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PlGF-3 is expressed exclusively in the placenta. It signals through the VEGFR-1/FLT1 receptor and stimulates endothelial cell proliferation and migration. PlGF-3 lacks heparin binding affinity. Recombinant human PlGF-3 is a 45.7 kDa disulfide-linked homodimeric protein of two 203 amino acid polypeptide chains.

• Synonyms :

  PlGF; placental growth factor

• NCBI Gene ID :

  5228

• UniProt :

  P49763-1

• Accession Number :

  NP_001193941.1

• Accession Number mRNA :

  NM_001207012.1

• Chromosomal Location :

  2p21-p16

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRHSPGRQS PDMPGDFRAD APSFLPPRRS LPMLFRMEWG CALTGSQSAV WPSSPVPEEI PRMHPGRNGK KQQRKPLREK MKPERCGDAV PRR

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-50.0 ng/ml.

• Length :

  203

• Form :

  Lyophilized

• Molecular Weight :

  45,7 kDa

• Host or Source :

  E. coli