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PDGF-CC

CAT: 0209-100-354-L1000Size: 4x 250 µgDry Ice: NoHazardous: No
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CAT#:0209-100-354-L1000Size:4x 250 µg
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Description
The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25 kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.
Synonyms
PDGF-CC
NCBI Gene ID
56034
UniProt
Q9NRA1
Accession Number
NP_057289.1
Accession Number mRNA
NM_016205.2
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/ml.
Length
114
Form
Lyophilized
Molecular Weight
25 kDa
Host or Source
E. coli

UniProtKB · Q9NRA1

Platelet-derived growth factor C

PDGFC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NRA1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDGFC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PDGF-C
EC number
—
Processing
Precursor
Secondary accessions
B4DU34, B9EGR8, Q4W5M9, Q9UL22
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembraneNucleusSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinUbl conjugation

Molecular function

Developmental proteinGrowth factorMitogen

Technical term

Proteomics identificationReference proteome

Domain

Signal

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YP-W12798-01Human PDGF-CC (PDGF-CC) ELISA Kit
PT-A04145-01PDGF CC Human
MBS692065-01Human PDGF-CC
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HC711290Human PDGF CC
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BL10301_RRecombinant Human PDGF-CC
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