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MMP-1

CAT: 0209-100-419-L1000Size: 2x 500 µgDry Ice: NoHazardous: No
CAT#:0209-100-419-L1000Size:2x 500 µg
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Description
Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens. Recombinant human MMP-1 is a 42.7 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain which is involved in substrate specificity and in binding TIMP-1.
Synonyms
Matrix metalloproteinase-1, fibroblast collagenase, interstitial collagenase
NCBI Gene ID
4312
UniProt
P03956
Accession Number
NP_002412.1
Accession Number mRNA
NM_002421.3
Chromosomal Location
11q22.3
Reactivity
Human
Cross Reactivity
Human
Sequence
MFVLTEGNPR WEQTHLTYRI ENYTPDLPRA DVDHAIEKAF QLWSNVTPLT FTKVSEGQAD IMISFVRGDH RDNSPFDGPG GNLAHAFQPG PGIGGDAHFD EDERWTNNFR EYNLHRVAAH ELGHSLGLSH STDIGALMYP SYTFSGDVQL AQDDIDGIQA IYGRSQNPVQ PIGPQTPKAC DSKLTFDAIT TIRGEVMFFK DRFYMRTNPF YPEVELNFIS VFWPQLPNGL EAAYEFADRD EVRFFKGNKY WAVQGQNVLH GYPKDIYSSF GFPRTVKHID AALSEENTGK TYFFVANKYW RYDEYKRSMD PGYPKMIAHD FPGIGHKVDA VFMKDGFFYF FHGTRQYKFD PKTKRILTLQ KANSWFNCRK N
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 90% by SDS-PAGE & HPLC analysis
Bioactivity
MMP-1 activity was measured by its ability to cleave a chromogenic peptide MMP-1 substrate at room temperature. At an MMP-1 concentration of 2.5 μg/ml, 50% cleavage was achieved at an incubation time of approximately 25 minutes
Length
371
Form
Lyophilized
Molecular Weight
42.7 kDa
Host or Source
E. coli

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