MMP-3

CAT: 0209-101-M110Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M110Size:100 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP3 (stromelysin1), can degrade a broad range of substrates including collagen α chains, aggrecan, laminin, fibronectin, elastin, casein, α1 antitrypsin, myelin basic protein, IL1β, IGFBP3, pro MMP1, pro MMP7, pro MMP8, pro MMP9 and pro MMP13. MMP3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP3 in roles other than direct tissue remodelling, for instance, enzyme cascades and cytokine regulation. MMP3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells and macrophages. Structurally, MMP3 may be divided into several distinct domains; a prodomain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexinlike) domain.
Synonyms
MMP3; SL-1; STMY; STR1; CHDS6; MMP-3; STMY1
NCBI Gene ID
4314
UniProt
P08254
Accession Number
NP_002413.1
Accession Number mRNA
NM_002422.3
Chromosomal Location
11q22.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human MMP-3
Clone
(#3E44)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: Use at 1:500-1000; IHC: 1:200-400
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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