Leptin

• Description :

  Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant human Leptin is a 16.0 kDa protein containing 147 amino acid residues.

• Synonyms :

  LEP; OB; OBS

• NCBI Gene ID :

  3952

• UniProt :

  P41159

• Accession Number :

  NP_000221.1

• Accession Number mRNA :

  NM_000230

• Chromosomal Location :

  7q31.1

• Reactivity :

  Human

• Cross Reactivity :

  Chicken, Monkey, Mouse, Rat, Human

• Sequence :

  MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.

• Length :

  147

• Form :

  Lyophilized

• Molecular Weight :

  16 kDa

• Host or Source :

  E. coli