Leptin

CAT: 0209-R20-033SSize: 200 µgDry Ice: NoHazardous: No
CAT#:0209-R20-033SSize:200 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.
Synonyms
Lep; ob; obese
NCBI Gene ID
25608
UniProt
P50596
Accession Number
NP_037208
Accession Number mRNA
NM_013076
Chromosomal Location
4q22
Reactivity
Rat
Cross Reactivity
Mouse, Rat
Sequence
MVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5µg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
Length
147
Form
Lyophilized
Molecular Weight
16.2 kDa
Host or Source
E. coli

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MBS8577915-01Leptin
cyt-1109-01Leptin-A

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