Leptin

• Description :

  Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.

• Synonyms :

  Lep; ob; obese

• NCBI Gene ID :

  16846

• UniProt :

  P41160

• Accession Number :

  NP_032519.1

• Accession Number mRNA :

  NM_008493.3

• Chromosomal Location :

  6 A3.3; 6 10.5 cM

• Reactivity :

  Mouse

• Cross Reactivity :

  Hamster, Human, Pig, Rat, Mouse

• Sequence :

  MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 14 days. Significant effects on body weight , food consumption, and plasma glucose levels were observed to saline-treated controls.

• Length :

  147

• Form :

  Lyophilized

• Molecular Weight :

  16.2 kDa

• Host or Source :

  E. coli