IL-5

• Description:

  IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant human IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.

• Synonyms:

  IL5; EDF; TRF; IL-5

• NCBI Gene ID:

  3567

• UniProt:

  P05113

• Accession Number:

  NP_000840.1

• Accession Number mRNA:

  NM_000879

• Chromosomal Location:

  5q31.1

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human, Guinea Pig

• Sequence:

  MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 0.15 ng/ml, corresponding to a specific activity of ≥ 6.6 x 106 units/mg.

• Length:

  116

• Form:

  Lyophilized

• Molecular Weight:

  26 kDa

• Host or Source:

  E. coli