IL-4

• Description:

  Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1) . IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

• Synonyms:

  Il4; Il4e12

• NCBI Gene ID:

  287287

• UniProt:

  P20096

• Accession Number:

  NP_958427

• Accession Number mRNA:

  NM_201270

• Chromosomal Location:

  10q22

• Reactivity:

  Rat

• Cross Reactivity:

  Mouse, Rat, Human

• Sequence:

  MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Tested by its ability to suppress LPS-induced TNF-α and MIP-2 production in mouse splenocytes.

• Length:

  126

• Form:

  Lyophilized

• Molecular Weight:

  14 kDa

• Host or Source:

  E. coli