IL-4/Interleukin 4

• Gene Name:

  [IL-4]

• NCBI Gene ID:

  3565

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

• Other Gene Names:

  [IL4; IL4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1; IL-4; BSF-1]

• Short Name:

  [IL-4/Interleukin 4]

• Other Product Names:

  [interleukin-4 isoform 1; Interleukin-4; interleukin-4; interleukin 4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra]

• NCBI GI Number:

  4504669

• NCBI Accession Number:

  NP_000580.1

• NCBI GB Accession Number:

  NP_000580.1

• Uniprot Accession Number:

  P05112