IL-4

• Description :

  Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1) . IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

• Synonyms :

  Il4; Il4e12

• NCBI Gene ID :

  287287

• UniProt :

  P20096

• Accession Number :

  NP_958427

• Accession Number mRNA :

  NM_201270

• Chromosomal Location :

  10q22

• Reactivity :

  Rat

• Cross Reactivity :

  Mouse, Rat, Human

• Sequence :

  MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Tested by its ability to suppress LPS-induced TNF-α and MIP-2 production in mouse splenocytes.

• Length :

  126

• Form :

  Lyophilized

• Molecular Weight :

  14 kDa

• Host or Source :

  E. coli