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IL-35

CAT: 0209-100-164-L500Size: 10x 50 µgDry Ice: NoHazardous: No
CAT#:0209-100-164-L500Size:10x 50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-35 is a glycosylated, heterodimeric protein consisting of the p35 subunit from IL-12 (IL-12α) and the β subunit from IL-27 (EBI3) . IL-35 can be expressed by regulatory T-cells (Tregs), macrophages, and certain trophoblast and dendritic cells. It is induced in response to inflammation, and generally acts as an inflammation suppressor. IL-35 suppresses inflammation by exerting multiple activities, including the induction of regulatory T-cells and the suppression of Th17 cells. Recombinant Human IL-35 produced from HEK293 cells is a glycosylated protein, primarily heterodimeric, that migrates as a diffuse band centered at an apparent molecular weight of about 60 kDa by SDS-PAGE analysis under non-reducing conditions. Recombinant Human IL-35 expressed in HEK293 cells contains 406 amino acid residues and has a calculated molecular weight of 45.8 kDa.
Synonyms
Interleukin-35
NCBI Gene ID
Alpha: 3592 Beta: 10148
UniProt
Alpha: P29459 Beta: Q14213
Accession Number
Alpha: NP_001384921 Beta: NP_005746
Accession Number mRNA
Alpha: NM_001397992 Beta: NM_005755
Reactivity
Human
Cross Reactivity
Human, Mouse
Sequence
Α Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS β Subunit: RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 90% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Measured by its ability to inhibit proliferative activity of PBMCs.
Length
406
Form
Lyophilized
Molecular Weight
45.8 kDa
Host or Source
HEK 293 cells

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