IL-2

• Description:

  IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant murine IL-2 is a 17.2 kDa protein, containing 149 amino acid residues.

• Synonyms:

  Il2; Il-2

• NCBI Gene ID:

  16183

• UniProt:

  P04351

• Accession Number:

  NP_032392.1

• Accession Number mRNA:

  NM_008366.3

• Chromosomal Location:

  3 B-C; 3 19.2 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse, Leech

• Sequence:

  PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose dependent stimulation of murine CTLL-2 cells is < 0.2 ng/ml, corresponding to a specific activity of > 5 x 106 units/mg.

• Length:

  149

• Form:

  Lyophilized

• Molecular Weight:

  17.2 kDa

• Host or Source:

  E. coli