RegisterLogin

IL-12

CAT: 0209-100-051-L1000Size: 2x 500 µgDry Ice: NoHazardous: No
100-051-L10002x 500 µg
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues) .
Synonyms
Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF
NCBI Gene ID
P35: 3592; p40: 3593
UniProt
P35: P29459; p40: P29460
Accession Number
P35: NP_000873.2; p40: NP_002178.2
Accession Number mRNA
P35: NM_000882.4; p40: NM_002187.3
Chromosomal Location
3q25.33-q26
Reactivity
Human
Cross Reactivity
Monkley, Mouse, Human, Leech
Sequence
P35 Subunit: RNLPVA TPDPGMFPCL HHSQNLLRAV SNMLQKARQT LEFYPCTSEE IDHEDITKDK TSTVEACLPL ELTKNESCLN SRETSFITNG SCLASRKTSF MMALCLSSIY EDLKMYQVEF KTMNAKLLMD PKRQIFLDQN MLAVIDELMQ ALNFNSETVP QKSSLEEPDF YKTKIKLCIL LHAFRIRAVT IDRVMSYLNA S p40 Subunit: IWELKK DVYVVELDWY PDAPGEMVVL TCDTPEEDGI TWTLDQSSEV LGSGKTLTIQ VKEFGDAGQY TCHKGGEVLS HSLLLLHKKE DGIWSTDILK DQKEPKNKTF LRCEAKNYSG RFTCWWLTTI STDLTFSVKS SRGSSDPQGV TCGAATLSAE RVRGDNKEYE YSVECQEDSA CPAAEESLPI EVMVDAVHKL KYENYTSSFF IRDIIKPDPP KNLQLKPLKN SRQVEVSWEY PDTWSTPHSY FSLTFCVQVQ GKSKREKKDR VFTDKTSATV ICRKNASISV RAQDRYYSSS WSEWASVPCS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: The ED50 as determined by the induction of IFN-γ from NK cells co-stimulated with IL-18 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Assay #2: Determined by its ability to increase IFN-γ production by anti-TCR mAb-stimulated PBMCs. The expected ED50 for this effect is 4.0-8.0 ng/ml.
Length
503
Form
Lyophilized
Molecular Weight
75 kDa
Host or Source
CHO cells

Related Products

CatalogName
100-391FGF-12
100-391SFGF-12
100-391-L1000FGF-12
101-M114MMP-12
100-161SIL-37 (IL-1F7)
100-161-L250IL-37 (IL-1F7)
100-161IL-37 (IL-1F7)
101-M784IL-18 (IL-1F4)
100-161-L500IL-37 (IL-1F7)
100-161-L100IL-37 (IL-1F7)

Alternative Products

CatalogName
E57V1401IL-12
E52Y04001IL-12
GWB-EA2B03IL-12
GWB-F5C81FIL-12
MBS8577811-01IL-12
E8ER1911-22IL-12
Y04001-01IL-12
E21-M39Interleukin-12/IL-12
I8434-06GInterleukin 12 (IL-12)
MBS8533020-01Interleukin-12/IL-12

Popular Products