IFNA2 / Interferon alpha 2 Protein (hFc Tag)

• Description:

  IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-α genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.

• Synonyms:

  If1ai7 Protein; Ifa2 Protein; Ifna2 Protein

• Accession Number:

  P01573

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Label:

  HFc-Tag

• Assay Protocol:

  See Datasheet send with the product

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method

• Purity:

  > 95 % as determined by SDS-PAGE

• Bioactivity:

  1. Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV) . The ED50 for this effect is 1-8 ng/mL. 2. Immobilized Mouse IFNAR1 His at 2 μg/mL (100 μL/well) can bind Mouse Interferon alpha 2/IFNA2 hFc. The EC50 of Mouse Interferon alpha 2/IFNA2 hFc is 10-80 ng/mL.

• Length:

  427

• Form:

  Lyophilized

• Buffer:

  PBS, pH 7.4

• Reconstitution:

  See Datasheet

• Molecular Weight:

  52 kDa (glycosylated monomer)

• Storage Conditions:

  Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

• Host or Source:

  HEK 293 cells