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IL-28A

CAT: 0209-M10-029Size: 20 µgDry Ice: NoHazardous: No
CAT#:0209-M10-029Size:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumour activity. IL-28A acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1, IFN-lambda 2 and IFN-lambda 3 are closely positioned genes on human chromosome 19. IL-28A induces ELR (-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-28A is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-28A produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.
Synonyms
Interferon lambda-2, IFN-lambda-2, Interleukin-28A, IL-28A, Ifnl2, Il28a, EG330496
NCBI Gene ID
330496
UniProt
Q4VK74
Accession Number
NP_001019844.2
Accession Number mRNA
NM_001024673.2
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
DPVPRATRLP VEAKDCHIAQ FKSLSPKELQ AFKKAKDAIE KRLLEKDMRC SSHLISRAWD LKQLQVQERP KALQAEVALT LKVWENMTDS ALATILGQPL HTLSHIHSQL QTCTQLQATA EPKPPSRRLS RWLHRLQEAQ SKETPGCLED SVTSNLFRLL TRDLKCVASG DQCV
Assay Protocol
It is recommended to reconstitute the lyophilized IL-28A in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis (EMC) virus is less than 3 ng/ml, corresponding to a specific activity of > 3.3 x 105 IU/mg.
Length
174
Form
Lyophilized
Buffer
PBS/5% Trehalose
Reconstitution
Water
Molecular Weight
19.7kDa
Storage Conditions
Lyophilized mouse IL-28A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C.
Host or Source
E. coli

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