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IFN lambda2

CAT: 0209-102-P231Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P231Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human/mouse IFN-lambda 2 or IL-28A, IL-28B (or IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity) . These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1) . Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.
Synonyms
IL29; IFNL1; IL-29
NCBI Gene ID
282616
UniProt
Q8IZJ0
Accession Number
NP_742150.1
Accession Number mRNA
NM_172138
Chromosomal Location
19q13.13
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IFN-lambda2
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

UniProtKB · Q8IZJ0

Interferon lambda-2

IFNL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IZJ0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IFNL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IFN-lambda-2
EC number
—
Processing
Precursor
Secondary accessions
Q45KQ8, Q6VN55, Q8IWL7
Protein keywords

Biological process

Antiviral defense

Molecular function

Cytokine

PTM

Disulfide bond

Technical term

Proteomics identificationReference proteome

Cellular component

Secreted

Domain

Signal

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