BMP-4

• Description:

  Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.

• Synonyms:

  BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS7

• NCBI Gene ID:

  652

• UniProt:

  P12644

• Accession Number:

  NP_001193

• Accession Number mRNA:

  NM_001202

• Chromosomal Location:

  14q22-q23

• Reactivity:

  Human

• Cross Reactivity:

  Human, Mouse, Rat

• Sequence:

  HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR

• Purity:

  >97% by SDS-PAGE and HPLC anaylsis

• Bioactivity:

  Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.

• Length:

  113

• Form:

  Lyophilized

• Molecular Weight:

  25,6 kDa

• Host or Source:

  HeLa cells