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BMP-8

CAT: 0209-101-M239Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M239Size:100 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMP8, also known as osteogenic protein 2 (OP2), was first isolated from a hippocampal library in a screen to identify relatives of BMP7/ OP1. BMPs are a family of structurally and functionally related proteins and represent a subfamily of the transforming growth factor β (TGFβ) superfamily. BMPs are involved in a wide range of processes including embryogenesis, tissue morphogenesis, cell differentiation and migration, and tumorigenesis. Cellular responses to BMPs are mediated by heterooligomeric complexes of type I and type II serine/threonine kinase receptors . BMP8a and BMP8b, produced from separate genes, share 98% aa sequence identity in human but only 74% in mouse within the mature regions. Human BMP8a is synthesized as a 402 aa precursor protein that is cleaved between Arg263 and Ala264 to release the Cterminal mature protein. Mature human BMP 8a shares 90% and 68% aa sequence identity with mouse mature BMP8a and 8b, respectively. BMP8a is expressed during pregnancy in the deciduum and trophoblast cells, by inner root sheath cells of developing hair follicles, and by the epididymis and spermatids) . In the mouse it cooperates with BMP7 in the maintenance of spermatogenesis but is not required for the initiation of spermatogenesis (7, 8) . BMP8b, in contrast, is required for both the initiation and maintenance of spermatogenesis. BMP8a is induced during osteoblast differentiation at the onset of mineralization and during the osteogenic phase of bone repair in osteoblasts and osteocytes (1012) . BMP8a/b is also highly expressed in osteosarcomas.
Synonyms
BMP8B; OP2; BMP8
NCBI Gene ID
656
UniProt
P34820
Accession Number
NP_001711
Accession Number mRNA
NM_001720
Chromosomal Location
1p35-p32
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human BMP-8
Clone
(#1M37)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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