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BMP-2

CAT: 0209-200-002-L500Size: 500 µgDry Ice: NoHazardous: No
CAT#:0209-200-002-L500Size:500 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. BMP-2 is a heparin binding protein.
Synonyms
Bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
NCBI Gene ID
650
UniProt
P12643
Accession Number
NP_001191
Accession Number mRNA
NM_001200
Chromosomal Location
20p12
Reactivity
Human/Murine/Rat
Cross Reactivity
Human
Sequence
MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Assay Protocol
The lyophilized BMP-2 is best soluble in 50 mM acetic acid at a concentration of 0.1mg/ml but should be also soluble in most aqueous buffers when the pH is below 6.0.
Endotoxin
< 0.1 ng per µg of BMP-2
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by the ability of BMP-2 to induce alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 0.3-0.8 µg/ml.
Length
115
Form
Lyophilized
Buffer
50 mM acetic acid
Reconstitution
50mM acetic acid
Molecular Weight
26.0 kDa
Storage Conditions
Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted BMP-2 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles!
Host or Source
E. coli
N Terminal Sequence
MQAKHKQ

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