BMP receptor-2

CAT: 0209-101-M177Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M177Size:50 µg
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Description
Like other members of the TGFβ superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signl transduction. BMP receptor II (BMPR II or BMPR-2) is one of the five mammalian type II receptors (including TGFβRII, ActRII, ActRIIB, BMPRII and MISRII) for the TGFβ superfamily ligands. The type II receptors for TGFβ and activin bind ligands with high affinity by itself. In contrast, BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPRII mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPRII are highly conserved sharing 97% sequence identity.
Synonyms
BMPR2; BMR2; PPH1; BMPR3; BRK-3; T-ALK; BMPR-II
NCBI Gene ID
659
UniProt
Q13873
Accession Number
NP_001195.2
Accession Number mRNA
NM_001204.6
Chromosomal Location
2q33-q34
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human BMP RII extra cellular domain
Clone
(#9A10)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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