BMP-13/CDMP-2

• Description:

  BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.

• Synonyms:

  GDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MCOPCB6

• NCBI Gene ID:

  392255

• UniProt:

  P43028

• Accession Number:

  NP_038554.1

• Accession Number mRNA:

  NM_013526.1

• Chromosomal Location:

  8q22.1

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human

• Sequence:

  TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  >95% by SDS-PAGE & HPLC analysis

• Bioactivity:

  The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml.

• Length:

  120

• Form:

  Lyophilized

• Molecular Weight:

  27.0 kDa

• Host or Source:

  E. coli