4-1BB receptor, soluble

• Description :

  4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

• Synonyms :

  TNFRSF9; ILA; 4-1BB; CD137; CDw137

• NCBI Gene ID :

  3604

• UniProt :

  Q07011

• Accession Number :

  NP_003802.1

• Accession Number mRNA :

  NM_001561

• Chromosomal Location :

  1p36

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 97% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inibition was seen using a concentration of 1µg for both 4-1BBL and 4-1BBR.

• Length :

  167

• Form :

  Lyophilized

• Molecular Weight :

  17.7 kDa

• Host or Source :

  E. coli