IRGB10 (CT) Peptide

• Background:

  IRGB10 Antibody: IRGB10 is an inferno-inducible protein that is essential for the activation of DNA-sensing AIM2 inflammasome, and contributes to the activation of LPS-sensing caspase-11 and NLRP3 inflammasome. IRGB10 is part of a conserved signaling hub at the interface between cell-autonomous immunity and innate immune sensing pathways. IRGB10 targets cytoplasmic bacteria and compromises bacterial structural integrity. IRGB10 and LIGP2 act together to confer differential susceptibility against Chlamydia infection in mice.

• NCBI Gene ID:

  631323

• Swiss Prot:

  AGY29631

• Accession Number:

  AGY29631

• Type:

  Peptides

• Concentration:

  200 ug/mL

• Buffer:

  PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store IRGB10 (CT) Peptide at -20˚ C, stable for one year.

• Applications Notes:

  IRGB10 (CT) Peptideis used for blocking the activity of theIRGB10 (CT) Antibody

• NCBI Official Name:

  Predicted gene 12250

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Man et al. Cell 2016; 167 (2) :382-396.e17

• Background Reference 02:

  Bernstein-Hanley I et al. Proc Natl Acad Sci USA. 2006;103 (38) :14092-14097

• Background Reference 03:

  Miyairi I et al. J Immunol 2007; 179 (3) :1814-1824

• Background Reference 04:

  Coers J et al. J Immunol 2008; 180 (9) :6237-6245

• Other Product Names:

  IRGB10 Antibody: Immunity-related GTPase family member b10, Interferon-gamma-inducible p47 GTPase, Gm12250, OTTMUSG00000005723

• Tested Applications:

  Blocking

• Species:

  Mouse

• Protein ID:

  551032829

• Physical Properties:

  Liquid