IRGB10 (NT) Antibody

• Background:

  IRGB10 Antibody: IRGB10 is an inferno-inducible protein that is essential for the activation of DNA-sensing AIM2 inflammasome, and contributes to the activation of LPS-sensing caspase-11 and NLRP3 inflammasome. IRGB10 is part of a conserved signaling hub at the interface between cell-autonomous immunity and innate immune sensing pathways. IRGB10 targets cytoplasmic bacteria and compromises bacterial structural integrity. IRGB10 and LIGP2 act together to confer differential susceptibility against Chlamydia infection in mice.

• NCBI Gene ID:

  631323

• Swiss Prot:

  AGY29631

• Accession Number:

  AGY29631

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  9513

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Inflammasomes

• Purification:

  IRGB10 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1405 – Mouse Kidney Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat (100%), Hamster (85%)

• Buffer:

  IRGB10 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  IRGB10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Isoform:

  Mouse IRGB10 has 1 isoform (417aa, 47.2kD) .

• Symbol:

  IRGB10

• Positive Control 2:

  Cat. No. 1419 – Mouse Skin Lysate

• Positive Control 3:

  Cat. No. 1411 – Mouse Colon Lysate

• NCBI Official Name:

  Predicted gene 12250

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Man et al. Cell 2016; 167 (2) :382-396.e17

• Background Reference 02:

  Bernstein-Hanley I et al. Proc Natl Acad Sci USA. 2006;103 (38) :14092-14097

• Background Reference 03:

  Miyairi I et al. J Immunol 2007; 179 (3) :1814-1824

• Background Reference 04:

  Coers J et al. J Immunol 2008; 180 (9) :6237-6245

• Other Product Names:

  IRGB10 Antibody: Immunity-related GTPase family member b10, Interferon-gamma-inducible p47 GTPase, Gm12250, OTTMUSG00000005723

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  551032829

• Physical Properties:

  Liquid