SIGLEC15 Peptide

CAT: 0223-9017PSize: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-9017PSize:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig) -like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.
NCBI Gene ID
284266
Swiss Prot
Q6ZMC9
Accession Number
NP_998767
Type
Peptides
Concentration
200 ug/mL
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Shipping Conditions
Blue Ice
Storage Conditions
Store SIGLEC15 Peptide at -20˚ C, stable for one year.
Applications Notes
SIGLEC15 Peptide is used for blocking the activity of the SIGLEC15 Antibody
NCBI Official Name
Sialic acid binding Ig-like lectin 15
NCBI Organism
Homo sapiens
Background Reference 01
Crocker and Redelinghuys. Biochem. Soc. Trans. 2008; 36:1467-71.
Background Reference 02
Angata et al. Glycobiology 2007; 17:838-46.
Background Reference 03
Hiruma et al. Biochem. Biophys. Res. Commun. 2011; 409:424-9.
Other Product Names
SIGLEC15 Antibody: CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15
Tested Applications
Blocking
Species
Human
Protein ID
47106069
Physical Properties
Liquid

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