SIGLEC15 Antibody

• Background:

  SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig) -like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

• NCBI Gene ID:

  284266

• Swiss Prot:

  Q6ZMC9

• Accession Number:

  NP_998767

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  9017

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  SIGLEC15 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  SIGLEC15 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SIGLEC15 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Isoform:

  Human SIGLEC15 has 2 isoforms, including isoform 1 (328aa, 36kD) and isoform 2 (174aa, 18kD) . Mouse SIGLEC15 has one isoform (342aa, 37kD) and Rat SIGLEC15 also has one isoform (341aa, 37kD) . 9017 can detect human and possibly mouse and rat isoforms.

• Symbol:

  SIGLEC15

• Positive Control 2:

  Cat. No. 1211 - HepG2 Cell Lysate

• Positive Control 3:

  Cat. No. 1220 - SK-N-SH Cell Lysate

• Positive Control 4:

  Cat. No. 1304 - Human Liver Lysate

• Positive Control 5:

  Cat. No. 1404 - Mouse Liver Lysate

• Positive Control 6:

  Cat. No. 1463 - Rat brain Lysate

• NCBI Official Name:

  Sialic acid binding Ig-like lectin 15

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Crocker and Redelinghuys. Biochem. Soc. Trans. 2008; 36:1467-71.

• Background Reference 02:

  Angata et al. Glycobiology 2007; 17:838-46.

• Background Reference 03:

  Hiruma et al. Biochem. Biophys. Res. Commun. 2011; 409:424-9.

• Other Product Names:

  SIGLEC15 Antibody: CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15

• Tested Applications:

  ELISA, WB

• Protein ID:

  47106069

• Physical Properties:

  Liquid