BMP-3 Recombinant Protein

• Background:

  TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-3 is abundantly found in adult bone, and to a lesser extent fetal cartilage. BMP-3 inhibits osteogenesis and bone formation by activating a signaling cascade that antagonizes the signaling of pro-osteogenic BMPs. Recombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.

• NCBI Gene ID:

  651

• Swiss Prot:

  P12645

• Accession Number:

  NP_001192.2

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Growth Factors, Signal Transduction

• Purity:

  Greater than 95% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized BMP-3 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted BMP-3 stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing BMP-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Bone morphogenetic protein 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  BMP-3A, BMP3A, Bone morphogenetic protein 3, Bone morphogenetic protein 3A, BMP-3

• Species:

  Human

• Protein ID:

  126507087

• Physical Properties:

  Lyophilized