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PDGF-AB Recombinant Protein

CAT: 0223-40-512-01Size: 0.002 mgDry Ice: NoHazardous: No
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CAT#:0223-40-512-01Size:0.002 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α -granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-B. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-B interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids) .
NCBI Gene ID
5154;5155
Swiss Prot
P04085
Accession Number
NP_002598.4
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Cell Cycle, Growth Factors, Immunology, Obesity, Signal Transduction
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized PDGF-AB recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted PDGF-AB is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing PDGF-AB recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Platelet-derived growth factor alpha polypeptide
NCBI Organism
Homo sapiens
Other Product Names
PDGF1, PDGF-A, PDGF1, Platelet-derived growth factor subunit A, PDGF-1, PDGF subunit A
Species
Human
Protein ID
77695917
Physical Properties
Lyophilized

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