Midkine Recombinant Protein

• Background:

  Midkine (MK) and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK) . MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.

• NCBI Gene ID:

  4192

• Swiss Prot:

  P21741

• Accession Number:

  NP_001012333.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Neuroscience

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Midkine recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Midkine is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Midkine recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Midkine (neurite growth-promoting factor 2)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  MK, ARAP, NEGF2, MK1, Midkine, Amphiregulin-associated protein, MK

• Species:

  Human

• Protein ID:

  59894796

• Physical Properties:

  Lyophilized