Neuropoietin Recombinant Protein

• Background:

  Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway. Recombinant murine Neuropoietin is a 19.8 kDa protein containing 183 amino acid residues.

• NCBI Gene ID:

  244218

• Swiss Prot:

  P83714

• Accession Number:

  NP_942155.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Neuropoietin recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Neuropoietin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Neuropoietin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Cardiotrophin 2

• NCBI Organism:

  Mus musculus

• Other Product Names:

  NP, Gm494, Cardiotrophin-2, Neuropoietin, CT-2

• Species:

  Murine

• Protein ID:

  38524598

• Physical Properties:

  Lyophilized