IGF-BP4 Recombinant Protein

• Background:

  IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF independent pathway. The biological effects of IGF-BP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGF-BP4/IGF binding affinity by proteolytically cleaving IGF-BP4. The modulation of IGF-BP4 activity by PAPP-A is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells. Recombinant human IGF-BP4 is a 25.8 kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

• NCBI Gene ID:

  3487

• Swiss Prot:

  P22692

• Accession Number:

  NP_001543.2

• Type:

  Recombinant Proteins

• Field of Research:

  Cancer, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized IGF-BP4 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IGF-BP4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IGF-BP4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Insulin-like growth factor binding protein 4

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  BP-4, IBP4, IGFBP-4, HT29-IGFBP, Insulin-like growth factor-binding protein 4, IBP-4

• Species:

  Human

• Protein ID:

  62243290

• Physical Properties:

  Lyophilized