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IGF-BP5 Recombinant Protein

CAT: 0223-40-150-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-150-01Size:0.005 mg
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Background
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.
NCBI Gene ID
3488
Swiss Prot
P24593
Accession Number
NP_000590.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Apoptosis, Cancer, Cell Cycle, Signal Transduction, Other
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized IGF-BP5 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IGF-BP5 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IGF-BP5 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Insulin-like growth factor binding protein 5
NCBI Organism
Homo sapiens
Other Product Names
IBP5, IBP5, Insulin-like growth factor-binding protein 5, IBP-5
Species
Human
Protein ID
10834982
Physical Properties
Lyophilized

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