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VEGF-B Recombinant Protein

CAT: 0223-40-164-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-164-01Size:0.005 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
NCBI Gene ID
7423
Swiss Prot
P49765
Accession Number
NP_001230662.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Neuroscience, Signal Transduction
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized VEGF-B recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted VEGF-B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing VEGF-B recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Vascular endothelial growth factor B
NCBI Organism
Homo sapiens
Other Product Names
VRF, VEGFL, VRF, Vascular endothelial growth factor B, VEGF-related factor, VEGF-B
Species
Human
Protein ID
344179103
Physical Properties
Lyophilized

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