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VEGF-A Recombinant Protein

CAT: 0223-91-589Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-589Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF) /vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessels and endothelial cell growth, increasing microvascular permeability, promoting cell migration and inhibiting apoptosis. Alternatively spliced transcript variants of VEGF-A encod either secreted or cell-associated isoforms. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
CAS Number
9000-83-3
NCBI Gene ID
7422
Swiss Prot
P15692
Accession Number
P15692
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Cell Cycle, Growth Factors, Obesity, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
14.2 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Vascular endothelial growth factor A
NCBI Organism
Homo sapiens
Other Product Names
Vascular endothelial growth factor A, VEGFA, VEGF-A, Vascular permeability factor, VPF, VEGF, VEGF121, VEGF 121
Species
Human
Physical Properties
Lyophilized

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