VEGF-A Recombinant Protein

• Background:

  Vascular endothelial growth factor (VEGF/VEGF-A) is originally known as vascular permeability factor (VPF) . It belongs to the PDGF family with a cysteine-knot structure comprised of eight conserved cysteine residues, and reckoned as a potent mediator in the process of angiogenesis and vasculogenesis in either fetus or adult. VEGF is particularly expressed in supraoptic , paraventricular nuclei and the choroid plexus of the pituitary, and abundant in the corpus luteum of the ovary and in kidney glomeruli. The rat VEGF protein contains a putative 20 amino acids (aa) signal peptide, and alternative splicing of rat VEGF gene produces isoforms of 120, 144, 164 and 188 aa. Rat VEGF164 respectively displays 97% and 88% aa identity with that regions of mouse and human VEGF. VEGF can bind to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin, and play important roles in inducing endothelial cell proliferation, promoting cell migration, inhibiting apoptosis and inducing permeabilization of blood vessels.

• NCBI Gene ID:

  83785

• Swiss Prot:

  P16612-2

• Accession Number:

  P16612-2

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  P. pastoris

• Field of Research:

  Growth Factors, Signal Transduction

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  19.2 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Vascular endothelial growth factor A

• NCBI Organism:

  Rattus norvegicus

• Other Product Names:

  Vascular endothelial growth factor A, Vascular permeability factor, VEGF/VEGF-A/VPF, VEGF 164

• Species:

  Rat

• Protein ID:

  530394832

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3