TIMP-2 Recombinant Protein

• Background:

  TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8 kDa protein containing 194 amino acid residues.

• NCBI Gene ID:

  7077

• Swiss Prot:

  P16035

• Accession Number:

  NP_003246.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Signal Transduction, Other

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized TIMP-2 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TIMP-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TIMP-2 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  TIMP metallopeptidase inhibitor 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DDC8, CSC-21K, Metalloproteinase inhibitor 2, TIMP-2

• Species:

  Human

• Protein ID:

  4507511

• Physical Properties:

  Lyophilized