BDNF Antibody (biotin)

• Background:

  Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non neuronal cells. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients. In addition, functional studies showed that age-associated changes in BDNF-mediated pathways can enhance inflammation and increase myocardial injury after myocardial infarction in the aging heart.

• NCBI Gene ID:

  627

• Swiss Prot:

  P23560

• Accession Number:

  P23560

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBDNF (human BDNF) .

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Primary Antibodies, Antibody Pairs

• Field of Research:

  Neuroscience, Growth Factors, Stem Cell

• Purification:

  Anti-hBDNF specific antibody was purified by affinity chromatography and then biotinylated.

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  BDNF antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

• Symbol:

  BDNF

• NCBI Official Name:

  Brain-derived neurotrophic factor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ANON2, BULN2Brain-derived neurotrophic factor, Abrineurin, BDNF

• Tested Applications:

  WB

• Protein ID:

  114900

• Physical Properties:

  Lyophilized