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Bim Antibody [1C2C8]

CAT: 0223-PM-4819-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-PM-4819-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Bim Monoclonal Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
NCBI Gene ID
10018
Swiss Prot
O43521
Accession Number
NP_619527
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim.
Clonality
Monoclonal
Clone
1C2C8
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
Bim Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Positive Control
Cat. No. 95-107 - Bim Recombinant Protein
Concentration
1 mg/mL
Buffer
Bim Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Bim monoclonal antibody can be stored at -20˚ C, stable for one year.
Fragment
IgG1
Symbol
BCL2L11
Positive Control 2
Cat. No. 17-004 - K-562 Cell Slide
NCBI Official Name
BCL2-like 11 (apoptosis facilitator)
NCBI Organism
Homo sapiens
Background Reference 01
O'Connor L, Strasser A, O'Reilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998; 17:384-395.
Background Reference 02
Hsu SY, Lin P, and Hsueh AJ BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 1998; 12:1432-40.
Other Product Names
Bim Antibody [1C2C8] : BAM, BIM, BOD
Tested Applications
ELISA, WB, ICC, IF
Protein ID
20336315
Physical Properties
Liquid

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