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Bim Antibody [1C2H4]

CAT: 0223-PM-4821-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-PM-4821-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Bim Monoclonal Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
NCBI Gene ID
10018
Swiss Prot
O43521
Accession Number
NP_619527
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim.
Clonality
Monoclonal
Clone
1C2H4
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
Bim Monoclonal Antibody is Protein A purified.
Positive Control
Cat. No. 95-107 - Bim Recombinant Protein
Concentration
1 mg/mL
Buffer
Bim Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Bim monoclonal antibody can be stored at -20˚ C, stable for one year.
Fragment
IgG1
Symbol
BCL2L11
Positive Control 2
Cat. No. 17-004 - K-562 Cell Slide
NCBI Official Name
BCL2-like 11 (apoptosis facilitator)
NCBI Organism
Homo sapiens
Background Reference 01
O'Connor L, Strasser A, O'Reilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998; 17:384-395.
Background Reference 02
Hsu SY, Lin P, and Hsueh AJ BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 1998; 12:1432-40.
Other Product Names
Bim Antibody [1C2H4] : BAM, BIM, BOD
Tested Applications
ELISA, WB, ICC, IF
Protein ID
20336315
Physical Properties
Liquid

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