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PUMA Antibody [2A8F6]

CAT: 0223-PM-4523-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-PM-4523-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ . PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
NCBI Gene ID
27113
Swiss Prot
Q9BXH1
Accession Number
Q9BXH1
Host
Mouse
Reactivity
Human, Rat
Immunogen
Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
Clonality
Monoclonal
Clone
2A8F6
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/mL
Buffer
PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PUMA monoclonal antibody can be stored at -20˚ C, stable for one year.
Fragment
IgG1
Symbol
BBC3
Positive Control 2
Cat. No. 95-102 - PUMA Recombinant Protein
NCBI Official Name
BCL2 binding component 3
NCBI Organism
Homo sapiens
Background Reference 01
Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001; 7:683-94.
Background Reference 02
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001; 7:673-82.
Background Reference 03
Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001; 98:11318-23.
Other Product Names
PUMA Antibody [2A8F6] : JFY1, PUMA, JFY-1
Tested Applications
ELISA, WB
Protein ID
56748610
Physical Properties
Liquid

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