CD107a Antibody [H4A3]

• Background:

  CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

• NCBI Gene ID:

  3916

• Swiss Prot:

  P11279

• Accession Number:

  P11279

• Host:

  Mouse

• Reactivity:

  Human, Rhesus Monkey, African Green Monkey, Pigtail Macaque, Sooty Mangabey

• Immunogen:

  Human adherent peripheral blood cells

• Clonality:

  Monoclonal

• Clone:

  [H4A3]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Concentration:

  0.1 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG1

• Specificity:

  CD107a

• Applications Notes:

  CD107a Antibody [H4A3] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, and purification assays.

• Symbol:

  LAMP1

• NCBI Official Name:

  Lysosomal-associated membrane protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  LAMP-1, lysosome-associated membrane protein 1

• Tested Applications:

  Flow

• Physical Properties:

  Liquid