CD137 Antibody

• Background:

  CD137 is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.

• NCBI Gene ID:

  3604

• Swiss Prot:

  Q07011

• Accession Number:

  728738

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Human CD137.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -20˚ C.

• Specificity:

  Recognizes human CD137. Detects a band of ~29kDa by Western blot. Does not cross-react with mouse CD137.

• Applications Notes:

  Flow Cytometry: (1:500-1:1,000) . Western Blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 with 5% skim milk. Suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.

• Symbol:

  TNFRSF9

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 9

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  4-1BB; TNFRSF9

• Tested Applications:

  Flow, WB

• Protein ID:

  Q07011

• Physical Properties:

  Liquid