CD107b Antibody [H4B4] (PE)

• Background:

  CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

• NCBI Gene ID:

  3920

• Swiss Prot:

  P13473

• Accession Number:

  P13473

• Host:

  Mouse

• Reactivity:

  Human, Rhesus Monkey, African Green Monkey

• Immunogen:

  Human adherent peripheral blood cells

• Clonality:

  Monoclonal

• Clone:

  [H4B4]

• Conjugation:

  PE

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Obesity, Signal Transduction

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS/NaN3 and a stabilizing agent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG1

• Specificity:

  CD107b

• Applications Notes:

  CD107b Antibody [H4B4] for use in flow cytometry assays.

• Symbol:

  LAMP2

• NCBI Official Name:

  Lysosome-associated membrane glycoprotein 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  LAMP-2, lysosome-associated membrane protein 2

• Tested Applications:

  IHC-Fr, Flow

• Physical Properties:

  Liquid