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CD8beta Antibody [EP42]

CAT: 0223-99-246Size: 0.5 mgDry Ice: NoHazardous: No
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CAT#:0223-99-246Size:0.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In the chicken, the CD8 molecule is present in two forms - (i) a homodimer of two alpha chains and (ii) a heterodimer of an alpha chain and a beta chain. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8alpha- and CD8beta-chains, a relatively large proportion of the CD8+ TCR-gammadelta cells in the spleens of embryos and young chicks express only the alpha-chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved but there is a population of TCR-gammadelta CD8alphabeta cells in the chicken that is not found in rodents. Chicken CD8 is expressed on approximately 80% of thymocytes, 45% of blood mononuclear cells, and 50% of spleen cells but less than 1% of cells in the bursa and bone marrow. The monoclonal antibody EP42 recognizes the CD8beta chain.
NCBI Gene ID
396175
Host
Mouse
Reactivity
Chicken
Immunogen
Chicken splenocytes
Clonality
Monoclonal
Clone
[EP42]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2a
Specificity
CD8beta
Applications Notes
CD8beta Antibody [EP42] for use in flow cytometry, immunohistochemistry, and immunoprecipitation assays.
Symbol
CD8B
NCBI Official Name
CD8b molecule
NCBI Organism
Gallus gallus
Tested Applications
Flow, IP
Physical Properties
Liquid

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