CD40 Antibody [1C10]

• Background:

  CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.

• NCBI Gene ID:

  21939

• Swiss Prot:

  P27512

• Accession Number:

  P27512

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  SCD40

• Clonality:

  Monoclonal

• Clone:

  [1C10]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Innate Immunity

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2a

• Specificity:

  CD40

• Applications Notes:

  CD40 Antibody [1C10] for use in flow cytometry, immunoprecipitation, activation, and blocking assays.

• Symbol:

  Cd40

• NCBI Official Name:

  CD40 antigen

• NCBI Organism:

  Mus musculus

• Other Product Names:

  TNFRSF5, Bp50

• Tested Applications:

  WB, IHC-Fr, ICC, Flow

• Physical Properties:

  Liquid