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CD40 Antibody [1C10]

CAT: 0223-98-762Size: 0.5 mgDry Ice: NoHazardous: No
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CAT#:0223-98-762Size:0.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.
NCBI Gene ID
21939
Swiss Prot
P27512
Accession Number
P27512
Host
Rat
Reactivity
Mouse
Immunogen
SCD40
Clonality
Monoclonal
Clone
[1C10]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Innate Immunity
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2a
Specificity
CD40
Applications Notes
CD40 Antibody [1C10] for use in flow cytometry, immunoprecipitation, activation, and blocking assays.
Symbol
Cd40
NCBI Official Name
CD40 antigen
NCBI Organism
Mus musculus
Other Product Names
TNFRSF5, Bp50
Tested Applications
WB, IHC-Fr, ICC, Flow
Physical Properties
Liquid

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