CD22 Antibody [2D6]

• Background :

  CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.

• NCBI Gene ID :

  12483

• Swiss Prot :

  P35329

• Accession Number :

  P35329

• Host :

  Rat

• Reactivity :

  Mouse

• Immunogen :

  Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

• Clonality :

  Monoclonal

• Clone :

  [2D6]

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Stem Cell, Immunology

• Concentration :

  0.5 mg/mL

• Buffer :

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store vial at 2-8˚ C

• Fragment :

  IgG1

• Specificity :

  CD22

• Applications Notes :

  CD22 Antibody [2D6] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.

• Symbol :

  Cd22

• NCBI Official Name :

  CD22 antigen

• NCBI Organism :

  Mus musculus

• Other Product Names :

  Lyb-8, Leu-14, BL-CAM

• Tested Applications :

  ELISA, WB, IHC-P, Flow, IP

• Physical Properties :

  Liquid