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CD22 Antibody

CAT: 0223-79-684Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-684Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
NCBI Gene ID
933
Swiss Prot
P20273
Accession Number
NP_001762.2
Host
Rabbit
Reactivity
Human
Immunogen
CD22 antibody was raised against a peptide sequence around aa.839~843 (N-V-D-Y-V) derived from Human CD22.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
140 kDa
Specificity
This antibody detects endogenous level of total CD22 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
CD22
NCBI Official Name
CD22 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Doody G. M., Justement L. B., Delibrias C. C., Matthews R. J., Lin J., Thomas M. L., Fearon D. T. Science 269:242-244 (1995) Tuscano J. M., Engel P., Tedder T. F., Agarwal A., Kehrl J. H. Eur. J. Immunol. 26:1246-1252 (1996) Law C. L., Sidorenko S. P., Chandran K. A., Zhao Z., Shen S. H., Fischer E. H., Clark E. A. J. Exp. Med. 183:547-560 (1996)
Other Product Names
SIGLEC2, SIGLEC-2, RAF, SIGLEC2, FLJ22814, MGC130020
Tested Applications
WB
Protein ID
157168355
Physical Properties
Liquid

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