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CD22 Antibody [FR10B4]

CAT: 0223-33-491Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-33-491Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD22 mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProt]
NCBI Gene ID
933
Swiss Prot
P20273
Host
Mouse
Reactivity
Human
Immunogen
Human Burkitt’s lymphoma cells were used as the immunogen for the CD22 antibody.
Clonality
Monoclonal
Clone
FR10B4
Conjugation
Unconjugated
Type
Primary Antibodies, Antibody Pairs
Field of Research
Cancer, Stem Cell, Immunology
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
CD22
NCBI Official Name
CD22 molecule
NCBI Organism
Homo sapiens
Other Product Names
SIGLEC2, SIGLEC-2
Tested Applications
Functional Assays, Flow, IF
Physical Properties
Liquid

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