CD22 Antibody [FR10B4]

• Background:

  CD22 mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProt]

• NCBI Gene ID:

  933

• Swiss Prot:

  P20273

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human Burkitt’s lymphoma cells were used as the immunogen for the CD22 antibody.

• Clonality:

  Monoclonal

• Clone:

  FR10B4

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Antibody Pairs

• Field of Research:

  Cancer, Stem Cell, Immunology

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  CD22

• NCBI Official Name:

  CD22 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SIGLEC2, SIGLEC-2

• Tested Applications:

  Functional Assays, Flow, IF

• Physical Properties:

  Liquid