MDC1 (phospho Ser513) Antibody

• Background:

  The MDC1 protein contains a forkhead homology-associated (FHA) domain and 2 BRCA1 (MIM 113705) C-terminal motifs (BRCTs) and is required for the intra-S-phase DNA damage checkpoint.

• NCBI Gene ID:

  9656

• Swiss Prot:

  Q14676

• Accession Number:

  NP_055456.2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  MDC1 (phospho Ser513) antibody was raised against a peptide sequence around phosphorylation site of Serine 513 (E-R-S (p) -Q-A) derived from Human MDC1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  226 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of MDC1 only when phosphorylated at serine 513.

• Symbol:

  MDC1

• NCBI Official Name:

  Mediator of DNA-damage checkpoint 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nagase T., DNA Res. 3:17-24 (1996) .

• Background Reference 02:

  Shiina T., Genetics 173:1555-1570 (2006) .

• Background Reference 03:

  Mungall A.J., Nature 425:805-811 (2003) .

• Other Product Names:

  IER3, NFBD1, KIAA0170, DKFZp781A0122

• Tested Applications:

  IHC

• Protein ID:

  132626688

• Physical Properties:

  Liquid